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-synuclein, that is a major part of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) tension, advise that dysfunction in the intracellular proteinase techniques, including ubiquitin-proteasome technique or lysosomal process, which eliminates unnecessary toxic prot

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